>Even outside of smoking, nicotine is
associated with cardiovascular disease, potential birth defects, and poisoning.
Jerry JM, Collins GB, Streem D (2015). "E-cigarettes: Safe to recommend to patients?". Cleve Clin J Med 82 (8): 521–6. doi:10.3949/ccjm.82a.14054. PMID 26270431.
>Nictotine is a tumor promoter
Cardinale A, Nastrucci C, Cesario A, Russo P (January 2012). "Nicotine: specific role in angiogenesis, proliferation and apoptosis". Critical Reviews in Toxicology 42 (1): 68–89. doi:10.3109/10408444.2011.623150. PMID 22050423.
>Chronic nicotine use inhibits class I and II histone deacetylases in the striatum; this effect plays a role in addiction.
>By binding to nicotinic acetylcholine receptors, nicotine increases the levels of several neurotransmitters – acting as a sort of "volume control." It is thought that increased levels of dopamine in the reward circuits of the brain are a major contributor to the apparent euphoria and relaxation, and addiction caused by nicotine consumption.
Amir Levine; et al. (2011). "Molecular Mechanism for a Gateway Drug: Epigenetic Changes Initiated by Nicotine Prime Gene Expression by Cocaine". Sci Transl Med 3 (107): 107ra109. doi:10.1126/scitranslmed.3003062. PMC 4042673. PMID 22049069.
Volkow ND (November 2011). "Epigenetics of nicotine: another nail in the coughing". Sci Transl Med 3 (107): 107ps43. doi:10.1126/scitranslmed.3003278. PMC 3492949. PMID 22049068.
Fuck off with your mouth fedora garbage
