Did any nihilist, atheist, anti-natalist, or other severe contrarian ever actually WIN a large-scale public debate?

I think of Oxford-style debates, which have clear winners and losers, as judged by an audience. I also think of the Chomsky/Foucault debate (who won?). More generally, what history vindicates, and doesn't.

In contemporary Obama-tier political language, one might describe a group like ISIS as "nihilist", but /lit/ of course is smarter than this: ISIS is composed of true believers, theistic people who have been drawn to die for a principle that they believe in. All of this is antithetical to the above, despite how reprehensible their implementation is. ISIS are no "nihilists".

I bet there's some example among the Greeks that I don't know about. I assume that the above is actually quite hard to do, because all of human evolution is railing against the conclusion of the futility of existence, is primed to hate and shun such a conclusion - hence 4chan's current contempt for fedoras, edgelords, etc.

Making the above feat even harder is that people who are sincerely convinced of some flavor of futility, or of meaningless in godlessness, or of general irredeemable awfulness, will by the very nature of their sincerely held views be less motivated to try and win anything, since it's pointless.