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Quoted By: >>7621091
Hi /sci/entists
i was subjected to IFN-a for 12 weeks to eliminate a virus. This treatment made the microglia cells in my brain extremely sensitive towards various triggers. That destroys my ability to remember, to feel and to move.
I would welcome the return of my memory and researched methods to do so.
This method kills off the resident microglia and when the inhibitor is withdrawn, new, insensitive microglia repopulates throughout the CNS.
In mice 290mg / kg were fed for 21 days.
Microglia amount decreased by 50% in 3 days, 90% after 7 days and >99% within 21 days with no changes in cognition or behaviour.
my weight is 70kg.
i want a renewal of 90% of my brain wide microglia
70kg x 290mg = 20300mg = 20.3g
20.3g x 7 days = 142.1g (mouse model projected to myself)
142.1g inhibitor needed to eradicate 90% microglia.
since the inhibitor is toxic towards blood cells humans get 1000mg per day. Not 20300mg per day like in the mouse model.
1000mg per day results in an eradication of about 1% microglia cells per day. The same amount microglia renews itself in the same time.
my brain has about 25% 'sick' microglia.
How long does it take for the inhibitor to kill off these 25% microglia cells. Since the dose is much lower than in the mice model, the calculation cannot be 'after 7 days microglia decreased by 90%' because the microglia repopulates in the same time as it decreases. Can you follow me?
does the calculation gets logarithmic?
picture related. it's the mouse brain before and after inhibitor application.
i was subjected to IFN-a for 12 weeks to eliminate a virus. This treatment made the microglia cells in my brain extremely sensitive towards various triggers. That destroys my ability to remember, to feel and to move.
I would welcome the return of my memory and researched methods to do so.
This method kills off the resident microglia and when the inhibitor is withdrawn, new, insensitive microglia repopulates throughout the CNS.
In mice 290mg / kg were fed for 21 days.
Microglia amount decreased by 50% in 3 days, 90% after 7 days and >99% within 21 days with no changes in cognition or behaviour.
my weight is 70kg.
i want a renewal of 90% of my brain wide microglia
70kg x 290mg = 20300mg = 20.3g
20.3g x 7 days = 142.1g (mouse model projected to myself)
142.1g inhibitor needed to eradicate 90% microglia.
since the inhibitor is toxic towards blood cells humans get 1000mg per day. Not 20300mg per day like in the mouse model.
1000mg per day results in an eradication of about 1% microglia cells per day. The same amount microglia renews itself in the same time.
my brain has about 25% 'sick' microglia.
How long does it take for the inhibitor to kill off these 25% microglia cells. Since the dose is much lower than in the mice model, the calculation cannot be 'after 7 days microglia decreased by 90%' because the microglia repopulates in the same time as it decreases. Can you follow me?
does the calculation gets logarithmic?
picture related. it's the mouse brain before and after inhibitor application.
