Truth serums, amirite?

I have done a bit of reading into the subject but in terms of what is actually somewhat dependable and what can actually be created at home, I'm at a loss. I've been looking at Sodium thiopental, flunitrazepam, Midazolamx, alcohol, and especially Scopolamine.

So what works?
What can you make at home?
What's dangerous?
I'm thinking alcohol is about as good as it gets in terms of safety and ease, but what is the level of drunkenness to shoot for?