I've run into a snag while developing a setting for general "sandboxing" use.

The history of it involves the introduction of a curse instead of the supposed "confusion of tongues" in Biblical times, one which inflicts the existing people and anyone that "gains awareness of their own existence" with the loss of one of their senses.

The important part is that their body is physically unaffected, but they are inexplicably unable to comprehend the sensation after the curse is activated; a significant amount of people who claim to be blind/deaf/etc. would be seen with a justified skepticism.

Can you help me extrapolate the first city's reaction to this curse?

I also inquired /sci/ since I felt it had a scientific angle, but maybe this hour wasn't the best for them.