>>27544944 slot is just the most popular because its the most prevalent.
If you're at home and consolizing it, a 1-slot is more then adequate, since an MVS is literally just like any other cart based system. It just happens to have 1-6 carts in it at a time and a button that lets you swap between the active game. The primary reason the 4 slot was popular is because game swapping was rare in arcades, there was usually 4 games and thats it, maybe a handful on rotation or swapping between machines when a new game came in. This is a non-issue at home since you'll no doubt have the system unlocked (or if its consolized, just straight up exposed) and won't have to unlock the coin door, and then undo the latches and drop the control panel or get behind the thing and take the back panel off to swap the games
For OP:
Literally like 5 different ones, theres 60 in 1 I think, and it goes all the way up to the current 161 in 1. The 161 is the best and has most of the games you'd give a shit (Windjammers is the most notable exception, but Windjammers usually runs more then the cost of a multi-cart) about and a bunch of hacks and some duplicate games actually, which you will not give a shit about. Multi-carts are especially good for games that had yearly releases (KoF, some other fighters), or a lot of games and are popular and had quite a few games (Metal Slug). I personally don't own a multi-cart but I'm starting to consider it since I was looking at getting some expensive games.
I personally don't really like consolized systems, because its not the same as playing it on a cabinet. I know its the same game, using the same controls, but it just feels wrong if you're not standing besides a big red.
I'm currently rebuilding my control deck. I'm stripping the metal and repainting and sealing it (some parts have some surface rust), then putting in new buttons with switches and new sticks and a new control panel overlay.